BYU Releases Study on MS Predictions

  • 27 August 2015

Alison Wadsworth has lived with an MS diagnosis for 25 years. A new study introduces a method for predicting if the disease is about to intensify.  Photo by BYU Photo.

Article Highlights

  • Multiple sclerosis is a highly unpredictable disease.
  • A new BYU study introduces a method for predicting if multiple sclerosis is about to intensify.

“I would have loved knowing that there are many of us that manage to lead an almost-normal life with diet and exercise and lifestyle changes rather than becoming dependent on medicine that is very expensive.” —Alison Wadsworth, MS patient

Both the doctors who treat multiple sclerosis and the people who experience it agree that the disease is highly unpredictable.

While that remains true for the disease in general, a new study introduces a method for making personalized predictions.

The research is a culmination of an eight-year partnership between BYU statistician David Engler and researchers at Massachusetts General Hospital.

“The goal all along has been to develop personalized transition probabilities with regard to where they are in the disease process and where they’re most likely to go in the near future,” the BYU researcher said.

MS puts the body’s immune system against its nervous system. Forecasting the course of MS in an individual is a challenge because the disease can take so many different turns. And how a patient feels today is not very predictive of how they will feel in the near future.

Instead, Professor Engler’s method is based heavily on the individual patient’s history.

Every six months, people with MS share certain information with their doctor. First, they answer yes or no whether they experienced a “relapse.” Second, they estimate the intensity of their symptoms on a 21-point scale (0, 0.5, 1.0 … 9.0, 9.5, 10).

A doctor using the model would simply plug in the relapse and intensity information for the past two checkups, along with a few bits of demographic data.

The model then returns the odds that MS will retreat to a milder stage, advance to a more aggressive stage, or maintain the status quo in the next six months.

“If the model suggests you are likely to be in a more debilitated state six months from now, your doctor might recommend a more rigorous treatment regime,” he said.

The model can also reduce fears in other cases. Alison Wadsworth received her diagnosis 25 years ago and has continued a very active life. She says the literature she received after her diagnosis painted very dire pictures of the future.

“I would have loved knowing that there are many of us that manage to lead an almost-normal life with diet and exercise and lifestyle changes rather than becoming dependent on medicine that is very expensive,” she said.