(1) In Syria, an important city on the Orontes, founded 300 B.C. by Seleucus Nicator; in New Testament times the third city in the Roman Empire. It was the chief meeting point of East and West and a most disreputable city. During Paul’s life it was a center of gentile Christianity (Acts 6:5; 11:19–30; 13:1; 14:26; 15:22–35; 18:22; Gal. 2:11).