- Chapter 1
- Redemption comes through Christ—He created all things, is in the image of God, and is the Firstborn of the Father.
- Chapter 2
- The fulness of the Godhead dwells in Christ—Beware of being deceived by the traditions of men—The handwriting against us was nailed to the cross of Christ.
- Chapter 3
- Some lives are hidden with God in Christ—The Saints are told to be holy and to serve the Lord Jesus Christ.
- Chapter 4
- The Saints are told to be wise in all things—Luke and others greet the Colossians.